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詳細(xì)解析Cerilliant他克莫司T-049的藥理作用
發(fā)布時(shí)間： 2020-04-21 點(diǎn)擊次數(shù)： 1306次Cerilliant他克莫司T-049是一種非常好的免疫抑制劑，顧名思義，免疫抑制，就是能夠抑制免疫系統(tǒng)里的T淋巴細(xì)胞繼續(xù)攻擊黑色素，從而達(dá)到控制擴(kuò)散的目的。所以，用他克莫司以后，白斑不在擴(kuò)大，就是有效，白斑恢復(fù)，則為顯效；并不是說(shuō)，沒(méi)有恢復(fù)，就是無(wú)效的。Cerilliant他克莫司T-049藥性較強(qiáng)，一般用在臉上，都會(huì)有灼熱感，這是正常現(xiàn)象。Cerilliant他克莫司T-049的藥理作用：在分子水平，他克莫司的作用顯然是利用與細(xì)胞性蛋白質(zhì)（FKBP12）相結(jié)合，而在細(xì)胞內(nèi)蓄積產(chǎn)生效用。FKBP12-他克莫司復(fù)合物會(huì)專(zhuān)一性地結(jié)合以及抑制calcinurin，其會(huì)抑制T細(xì)胞中所產(chǎn)生鈣離子依賴(lài)型訊息傳導(dǎo)路徑作用，因此防止不連續(xù)性淋巴因子基因的轉(zhuǎn)錄。本藥是具有高度免疫抑制的藥物，其活性在體外及體內(nèi)實(shí)驗(yàn)中都已被證實(shí)。本藥抑制形成主要移植排斥作用之細(xì)胞毒性淋巴球的生成。本藥抑制T細(xì)胞的活化作用以及T輔助細(xì)胞依賴(lài)B細(xì)胞的增生作用。也會(huì)抑制如白介素-2、白介素-3及γ-干擾素等淋巴因子的生成與白介素-2受體的表達(dá)。在分子水平，本藥的效應(yīng)似乎是由結(jié)合到細(xì)胞性蛋白質(zhì)（FKBP）所產(chǎn)生，此蛋白質(zhì)也會(huì)造成該化合物累積在細(xì)胞間。在體內(nèi)試驗(yàn)中發(fā)現(xiàn)，本藥顯示出對(duì)肝臟及腎臟移植有效。
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